Effect of Simvastatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral arterial disease at six months and at one year after treatment

Simvastatin significantly increased treadmill exercise time until onset of intermittent claudication from baseline by 54 seconds (a 24% increase, p <0.0001) at 6 months after treatment and by 95 seconds (a 42% increase, p <0.0001) at I year after treatment. At 6 months and I year after treatment with placebo, treadmill exercise time until onset of intermittent claudication was not significantly different from baseline exercise time. (C) 2003 by Excerpta Medica, Inc.