Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections

被引：98

作者：

Adams, O

Besken, K

Oberdörfer, C

MacKenzie, CR

Takikawa, O

Däubener, W

机构：

[1] Univ Dusseldorf, Inst Med Mikrobiol, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Inst Virol, D-40225 Dusseldorf, Germany

[3] Hokkaido Univ, Dept Cell Pharmacol, Sapporo, Hokkaido 0608638, Japan

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 05期

关键词：

D O I：

10.1128/JVI.78.5.2632-2636.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gamma interferon (IFN-gamma)-mediated indoleamine-2,3-dioxygenase (IDO) activity in human astrocytoma cells and in native astrocytes was found to be responsible for the inhibition of herpes simplex virus replication. The effect is abolished in the presence of excess amounts Of L-tryptophan. Both IFN-alpha and IFN-beta restricted herpes simplex virus replication in both cell types, but (in contrast to the results seen with IFN-gamma) the addition of an excess amount Of L-tryptophan did not inhibit the induced antiviral effect.

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页码：2632 / 2636

页数：5

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