Orthology and functional conservation in eukaryotes

被引：70

作者：

Dolinski, Kara ^{[1
]}

Botstein, David ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

来源：

ANNUAL REVIEW OF GENETICS | 2007年 / 41卷

关键词：

comparative genomics; protein evolution; interspecies complementation;

D O I：

10.1146/annurev.genet.40.110405.090439

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In recent years, it has become clear that all of the organisms on the Earth are related to each other in ways that can be documented by molecular sequence comparison. In this review, we focus on the evolutionary relationships among the proteins of the eukaryotes, especially those that allow inference of function from one species to another. Data and illustrations are derived from specific comparison of eight species: Homo sapiens, Mus musculus, Arabidopsis thaliana, Caenorhabditis elegans, Danio rerio, Saccharomyces cerevisiae, and Plasmodium falciparum.

引用

页码：465 / 507

页数：43

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