Regulatory subunit interactions of the 26S proteasome, a complex problem

被引:191
作者
Ferrell, K
Wilkinson, CRM
Dubiel, W
Gordon, C
机构
[1] Humboldt Univ, Fac Med Charite, Inst Biochem, D-10117 Berlin, Germany
[2] Western Gen Hosp, MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland
关键词
D O I
10.1016/S0968-0004(99)01529-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The 26S proteasome is the major non-lysosomal protease in eukaryotic cells. This multimeric enzyme is the integral component of the ubiquitin-mediated substrate degradation pathway. It Consists of two subcomplexes, the 20S proteasome, which forms the proteolytic core, and the 19S regulator (or PA700), which confers ATP dependency and ubiquitinated substrate specificity on the enzyme. Recent biochemical and genetic studies have revealed many of the interactions between the 17 regulatory subunits, yielding an approximation of the 19S complex topology. Inspection of interactions of regulatory subunits with non-subunit proteins reveals patterns that suggest these interactions play a role in 26S proteasome regulation and localization.
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收藏
页码:83 / 88
页数:6
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