In vivo video rate optical coherence tomography

被引:386
作者
Rollins, AM [1 ]
Kulkarni, MD
Yazdanfar, S
Ung-arunyawee, R
Izatt, JA
机构
[1] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
关键词
D O I
10.1364/OE.3.000219
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
An optical coherence tomography system is described which can image up to video rate. The system utilizes a high power broadband source and real time image acquisition hardware and features a high speed scanning delay line in the reference arm based on Fourier-transform pulse shaping technology. The theory of low coherence interferometry with a dispersive delay line, and the operation of the delay line are detailed and the design equations of the system are presented. Real time imaging is demonstrated in vivo in tissues relevant to early human disease diagnosis (skin, eye) and in an important model in developmental biology (Xenopus laevis). (C)1998 Optical Society of America
引用
收藏
页码:219 / 229
页数:11
相关论文
共 28 条
[1]   Rapid and scalable scans at 21 m/s in optical low-coherence reflectometry [J].
Ballif, J ;
Gianotti, R ;
Chavanne, P ;
Walti, R ;
Salathe, RP .
OPTICS LETTERS, 1997, 22 (11) :757-759
[2]   Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography [J].
Boppart, SA ;
Tearney, GJ ;
Bouma, BE ;
Southern, JF ;
Brezinski, ME ;
Fujimoto, JG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (09) :4256-4261
[3]   Imaging developing neural morphology using optical coherence tomography [J].
Boppart, SA ;
Bouma, BE ;
Brezinski, ME ;
Tearney, GJ ;
Fujimoto, JG .
JOURNAL OF NEUROSCIENCE METHODS, 1996, 70 (01) :65-72
[4]  
GELIKONOV VM, 1996, 1996 OSA TECHNICAL D, V9, P58
[5]   RAPID SCANNING AUTO-CORRELATOR FOR MEASUREMENTS OF PICOSECOND LASER-PULSES [J].
HARDE, H ;
BURGGRAF, H .
OPTICS COMMUNICATIONS, 1981, 38 (03) :211-215
[6]  
HEE MR, 1992, THESIS MIT
[7]   OPTICAL COHERENCE TOMOGRAPHY [J].
HUANG, D ;
SWANSON, EA ;
LIN, CP ;
SCHUMAN, JS ;
STINSON, WG ;
CHANG, W ;
HEE, MR ;
FLOTTE, T ;
GREGORY, K ;
PULIAFITO, CA ;
FUJIMOTO, JG .
SCIENCE, 1991, 254 (5035) :1178-1181
[8]   RAPID-SCAN AUTOCORRELATOR FOR MONITORING CW MODE-LOCKED DYE-LASER PULSES [J].
ISHIDA, Y ;
YAJIMA, T ;
TANAKA, Y .
JAPANESE JOURNAL OF APPLIED PHYSICS, 1980, 19 (06) :L289-L292
[9]   Optical coherence tomography and microscopy in gastrointestinal tissues [J].
Izatt, JA ;
Kulkarni, MD ;
Wang, HW ;
Kobayashi, K ;
Sivak, MV .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 1996, 2 (04) :1017-1028
[10]   Velocity-estimation accuracy and frame-rate limitations in color Doppler optical coherence tomography [J].
Kulkarni, MD ;
van Leeuwen, TG ;
Yazdanfar, S ;
Izatt, JA .
OPTICS LETTERS, 1998, 23 (13) :1057-1059