Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces

被引：443

作者：

Esler, WP

Wolfe, MS ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

SCIENCE | 2001年 / 293卷 / 5534期

关键词：

D O I：

10.1126/science.1064638

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The amyloid beta -peptide (A beta) is a principal component of the cerebral plaques found in the brains of patients with Alzeheimer's disease (AD). This insoluble 40- to 42-amino acid peptide is formed by the cleavage of the A beta precursor protein (APP). The three proteases that cleave APP, alpha-, beta-, and gamma -secretases, have been implicated in the etiology of AD. beta -Secretase is a membrane-anchored protein with clear homology to soluble aspartyl proteases, and alpha -secretase displays characteristics of certain membrane-tethered metalloproteases. gamma -Secretase is apparently an oligomeric complex that includes the presenilins, which may be the catalytic component of this protease. Identification of the alpha-, beta-, and gamma -secretases provides potential targets for designing new drugs to treat AD.

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页码：1449 / 1454

页数：6

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