Notch signaling: Cell fate control and signal integration in development

被引：4876

作者：

Artavanis-Tsakonas, S ^{[1
]}

Rand, MD ^{[1
]}

Lake, RJ ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Cell Biol,Canc Ctr, Charlestown, MA 02129 USA

来源：

SCIENCE | 1999年 / 284卷 / 5415期

关键词：

D O I：

10.1126/science.284.5415.770

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.

引用

页码：770 / 776

页数：7

共 109 条

[1] INVOLVEMENT OF NOTCH-1 IN MAMMALIAN RETINAL NEUROGENESIS - ASSOCIATION OF NOTCH-1 ACTIVITY WITH BOTH IMMATURE AND TERMINALLY DIFFERENTIATED CELLS [J].