Urokinase plasminogen activator as a predictor of aggressive disease in breast cancer

被引：32

作者：

Duffy, MJ

Duggan, C

Maguire, T

Mulcahy, K

Elvin, P

McDermott, E

Fennelly, JJ

OHiggins, N

机构：

[1] ST VINCENTS HOSP,DEPT SURG,DUBLIN 4,IRELAND

[2] ST VINCENTS HOSP,DEPT MED ONCOL,DUBLIN 4,IRELAND

[3] ST BARTHOLOMEWS HOSP,DEPT GASTROENTEROL,LONDON,ENGLAND

[4] ZENECA PHARMACEUT,MACCLESFIELD,CHESHIRE,ENGLAND

来源：

ENZYME & PROTEIN | 1996年 / 49卷 / 1-3期

关键词：

urokinase plasminogen activator; breast cancer; prognosis; ELISA; mRNA;

D O I：

10.1159/000468618

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Urokinase plasminogen activator (uPA) is a multifunctional protein involved in both extracellular proteolysis and signal transduction. uPA usually mediates its actions while attached to a membrane-bound receptor, termed uPAR. In this study, uPA and its receptor were measured at both protein and mRNA levels in breast cancer. At both levels, concentrations of uPA were significantly correlated with those for uPAR. uPA levels also correlated significantly with cathepsin B and cathepsin D but not with cathepsin L, MMP-8 or MMP-9 levels. Irrespective of the cut-off point used (e.g., median, tertile or quartile values), uPA was a significant prognostic marker for breast cancer.

引用

页码：85 / 93

页数：9

共 35 条

[1] PRODUCTION OF 2ND MESSENGERS FOLLOWING CHEMOTACTIC AND MITOGENIC UROKINASE-RECEPTOR INTERACTION IN HUMAN FIBROBLASTS AND MOUSE FIBROBLASTS TRANSFECTED WITH HUMAN UROKINASE RECEPTOR [J].