Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

被引：114

作者：

Huang, Zhen ^{[1
]}

Zhong, Xiao-Ming ^{[1
]}

Li, Zhao-Yi ^{[1
]}

Feng, Chun-Rong ^{[1
]}

Pan, Ai-Juan ^{[1
]}

Mao, Qing-Qiu ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Coll Pharm, Hangzhou 310053, Zhejiang, Peoples R China

[2] Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2011年 / 493卷 / 03期

关键词：

Antidepressant; Brain-derived neurotrophic factor; Corticosterone; Curcumin; CHRONIC MILD STRESS; MESSENGER-RNA; EXPRESSION; SERUM; HIPPOCAMPUS; PROTEIN; MODEL;

D O I：

10.1016/j.neulet.2011.02.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration. This study aimed to examine the antidepressant-like effect and the possible mechanisms of curcumin in a CORT-induced depression model in rats. The results showed that 3-week CORT injections caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Repeated CORT injections also significantly decreased brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus and frontal cortex of the rats. Treatment of the rats with curcumin significantly suppressed the depression-like behavior and the decrease in brain BDNF levels induced by the repeated CORT injections. The results suggest that curcumin produces an antidepressant-like effect in CORT-treated rats, which is possibly mediated by increasing BDNF expression in the hippocampus and frontal cortex. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：145 / 148

页数：4

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