Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats

被引：114

作者：

Huang, Zhen ^{[1
]}

Zhong, Xiao-Ming ^{[1
]}

Li, Zhao-Yi ^{[1
]}

Feng, Chun-Rong ^{[1
]}

Pan, Ai-Juan ^{[1
]}

Mao, Qing-Qiu ^{[2
]}

机构：

[1] Zhejiang Chinese Med Univ, Coll Pharm, Hangzhou 310053, Zhejiang, Peoples R China

[2] Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2011年 / 493卷 / 03期

关键词：

Antidepressant; Brain-derived neurotrophic factor; Corticosterone; Curcumin; CHRONIC MILD STRESS; MESSENGER-RNA; EXPRESSION; SERUM; HIPPOCAMPUS; PROTEIN; MODEL;

D O I：

10.1016/j.neulet.2011.02.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration. This study aimed to examine the antidepressant-like effect and the possible mechanisms of curcumin in a CORT-induced depression model in rats. The results showed that 3-week CORT injections caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Repeated CORT injections also significantly decreased brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus and frontal cortex of the rats. Treatment of the rats with curcumin significantly suppressed the depression-like behavior and the decrease in brain BDNF levels induced by the repeated CORT injections. The results suggest that curcumin produces an antidepressant-like effect in CORT-treated rats, which is possibly mediated by increasing BDNF expression in the hippocampus and frontal cortex. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：145 / 148

页数：4

共 33 条

[1] Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women [J].

Aydemir, Cigdem ;

Yalcin, Esra Suer ;

Aksaray, Sabahat ;

Kisa, Cebrail ;

Yildirim, Sema Gulen ;

Uzbay, Tayfun ;

Goka, Erol .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2006, 30 (07) :1256-1260

[2] Serum brain-derived neurotrophic factor level in dysthymia:: A comparative study with major depressive disorder [J].

Aydemir, Oemer ;

Deveci, Artuner ;

Taskin, Oryal E. ;

Taneli, Fatma ;

Esen-Danaci, Aysen .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2007, 31 (05) :1023-1026

[3] Effects of fluoxetine and venlafaxine on serum brain derived neurotrophic factor levels in depressed patients [J].

Basterzi, Ayse Devrim ;

Yazici, Kemal ;

Aslan, Eda ;

Delialioglu, Nuran ;

Tasdelen, Bahar ;

Acar, Senel Tot ;

Yazici, Aylin .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (02) :281-285

[4] Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone [J].

Casarotto, P. C. ;

Andreatini, R. .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2007, 17 (11) :735-742

[5] Role of neurotrophic factors in depression [J].

Castren, Eero ;

Voikar, Vootele ;

Rantamaki, Tomi .

CURRENT OPINION IN PHARMACOLOGY, 2007, 7 (01) :18-21

[6] Melatonin treatment mimics the antidepressant action in chronic corticosterone-treated mice [J].

Crupi, Rosalia ;

Mazzon, Emanuela ;

Marino, Angela ;

La Spada, Giuseppina ;

Bramanti, Placido ;

Cuzzocrea, Salvatore ;

Spina, Edoardo .

JOURNAL OF PINEAL RESEARCH, 2010, 49 (02) :123-129

[7] Antidepressants reverse corticosterione-mediated decrease in brain-derived neurotrophic factor expression: Differential regulation of specific exons by antidepressants and corticosterone [J].

Dwivedi, Y. ;

Rizavi, H. S. ;

Pandey, G. N. .

NEUROSCIENCE, 2006, 139 (03) :1017-1029

[8] Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress [J].

Ibarguen-Vargas, Yadira ;

Surget, Alexandre ;

Vourc'h, Patrick ;

Leman, Samuel ;

Andres, Christian R. ;

Gardier, Alain M. ;

Belzung, Catherine .

BEHAVIOURAL BRAIN RESEARCH, 2009, 202 (02) :245-251

[9] Pharmacological characterization of repeated corticosterone injection-induced depression model in rats [J].

Iijima, Michihiko ;

Ito, Akie ;

Kurosu, Shinsuke ;

Chaki, Shigeyuki .

BRAIN RESEARCH, 2010, 1359 :75-80

[10] Noradrenergic and serotonergic blockade inhibits BDNF mRNA activation following exercise and antidepressant [J].

Ivy, AS ;

Rodriguez, FG ;

Garcia, C ;

Chen, MJ ;

Russo-Neustadt, AA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2003, 75 (01) :81-88

← 1 2 3 4 →