The transcriptional program of sporulation in budding yeast

被引：1445

作者：

Chu, S

DeRisi, J

Eisen, M

Mulholland, J

Botstein, D

Brown, PO ^{[1
]}

Herskowitz, I

机构：

[1] Stanford Univ, Howard Hughes Med Inst, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA

[3] Stanford Univ, Dept Biochem, Sch Med, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

来源：

SCIENCE | 1998年 / 282卷 / 5389期

关键词：

D O I：

10.1126/science.282.5389.699

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Diploid cells of budding yeast produce haploid cells through the developmental program of sporulation, which consists of meiosis and spore morphogenesis. DNA microarrays containing nearly every yeast gene were used to assay changes in gene expression during sporulation. At Least seven distinct temporal patterns of induction were observed. The transcription factor Ndt80 appeared to be important for induction of a Large group of genes at the end of meiotic prophase, Consensus sequences known or proposed to be responsible for temporal regulation could be identified solely from analysis of sequences of coordinately expressed genes. The temporal expression pattern provided clues to potential functions of hundreds of previously uncharacterized genes, some of which have vertebrate homologs that may function during gametogenesis.

引用

页码：699 / 705

页数：9

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