Bioactive cystine knot proteins

被引：140

作者：

Daly, Norelle L. ^{[1
]}

Craik, David J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, Brisbane, Qld 4072, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2011年 / 15卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

KAPPA-CONOTOXIN PVIIA; DRUG DESIGN; CIRCULAR PROTEINS; STRUCTURAL MOTIF; MOMORDICA-COCHINCHINENSIS; MACROCYCLIC PEPTIDES; INTEGRIN EXPRESSION; PLANT CYCLOTIDES; ALPHA-CONOTOXINS; LIVING SUBJECTS;

D O I：

10.1016/j.cbpa.2011.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we provide an update on the topology of the cystine knot and the combinatorial diversity of proteins that contain it. We describe recent chemical biology studies that have utilised this structural motif for the development of potential therapeutic or diagnostic agents. The cystine knot appears to have evolved in fungi, plants and animals as a stable and adaptable framework for the display of a wide variety of bioactive peptide sequences, but is amenable to chemical or recombinant synthesis and thus has a wide range of applications in chemistry, biology and medicine.

引用

页码：362 / 368

页数：7

共 71 条

[21] α-conotoxins:: Nicotinic acetylcholine receptor antagonists as pharmacological tools and potential drug leads [J].

Dutton, JL ;

Craik, DJ .

CURRENT MEDICINAL CHEMISTRY, 2001, 8 (04) :327-344

[22] NEW MOLLUSK-SPECIFIC ALPHA-CONOTOXINS BLOCK APLYSIA NEURONAL ACETYLCHOLINE-RECEPTORS [J].

FAINZILBER, M ;

HASSON, A ;

OREN, R ;

BURLINGAME, AL ;

GORDON, D ;

SPIRA, ME ;

ZLOTKIN, E .

BIOCHEMISTRY, 1994, 33 (32) :9523-9529

[23] Circular proteins in plants -: Solution structure of a novel macrocyclic trypsin inhibitor from Momordica cochinchinensis [J].

Felizmenio-Quimio, ME ;

Daly, NL ;

Craik, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) :22875-22882

[24] Biosynthesis of circular proteins in plants [J].

Gillon, Amanda D. ;

Saska, Ivana ;

Jennings, Cameron V. ;

Guarino, Rosemary F. ;

Craik, David J. ;

Anderson, Marilyn A. .

PLANT JOURNAL, 2008, 53 (03) :505-515

[25] Novel strategies for isolation and characterization of cyclotides:: The discovery of bioactive macrocyclic plant polypeptides in the Violaceae [J].

Göransson, U ;

Svangård, E ;

Claeson, P ;

Bohlin, L .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2004, 5 (05) :317-329

[26] KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007 [J].

Gracy, Jerome ;

Le-Nguyen, Dung ;

Gelly, Jean-Christophe ;

Kaas, Quentin ;

Heitz, Annie ;

Chiche, Laurent .

NUCLEIC ACIDS RESEARCH, 2008, 36 :D314-D319

[27] Distribution and Evolution of Circular Miniproteins in Flowering Plants [J].

Gruber, Christian W. ;

Elliott, Alysha G. ;

Ireland, David C. ;

Delprete, Piero G. ;

Dessein, Steven ;

Goransson, Ulf ;

Trabi, Manuela ;

Wang, Conan K. ;

Kinghorn, Andrew B. ;

Robbrecht, Elmar ;

Craik, David J. .

PLANT CELL, 2008, 20 (09) :2471-2483

[28] Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides [J].

Gunasekera, Sunithi ;

Foley, Fiona M. ;

Clark, Richard J. ;

Sando, Lillian ;

Fabri, Louis J. ;

Craik, David J. ;

Daly, Norelle L. .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (24) :7697-7704

[29] Knottin cyclization: impact on structure and dynamics [J].

Heitz, Annie ;

Avrutina, Olga ;

Le-Nguyen, Dung ;

Diederichsen, Ulf ;

Hernandez, Jean-Francois ;

Gracy, Jerome ;

Kolmar, Harald ;

Chiche, Laurent .

BMC STRUCTURAL BIOLOGY, 2008, 8

[30] Squash trypsin inhibitors from Momordica cochinchinensis exhibit an atypical macrocyclic structure [J].

Hernandez, JF ;

Gagnon, J ;

Chiche, L ;

Nguyen, TM ;

Andrieu, JP ;

Heitz, A ;

Hong, TT ;

Pham, TTC ;

Nguyen, DL .

BIOCHEMISTRY, 2000, 39 (19) :5722-5730

← 1 2 3 4 5 6 7 8 →