Bioactive cystine knot proteins

被引：140

作者：

Daly, Norelle L. ^{[1
]}

Craik, David J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, Brisbane, Qld 4072, Australia

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2011年 / 15卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

KAPPA-CONOTOXIN PVIIA; DRUG DESIGN; CIRCULAR PROTEINS; STRUCTURAL MOTIF; MOMORDICA-COCHINCHINENSIS; MACROCYCLIC PEPTIDES; INTEGRIN EXPRESSION; PLANT CYCLOTIDES; ALPHA-CONOTOXINS; LIVING SUBJECTS;

D O I：

10.1016/j.cbpa.2011.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cystine knot is a structural motif that confers exceptional stability on proteins. Here we provide an update on the topology of the cystine knot and the combinatorial diversity of proteins that contain it. We describe recent chemical biology studies that have utilised this structural motif for the development of potential therapeutic or diagnostic agents. The cystine knot appears to have evolved in fungi, plants and animals as a stable and adaptable framework for the display of a wide variety of bioactive peptide sequences, but is amenable to chemical or recombinant synthesis and thus has a wide range of applications in chemistry, biology and medicine.

引用

页码：362 / 368

页数：7

共 71 条

[1]

Adams DJ, 1999, DRUG DEVELOP RES, V46, P219

[2] Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy [J].

Akcan, Muharrem ;

Stroud, Mark R. ;

Hansen, Stacey J. ;

Clark, Richard J. ;

Daly, Norelle L. ;

Craik, David J. ;

Olson, James M. .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (03) :782-787

[3] Biosynthesis and Biological Screening of a Genetically Encoded Library Based on the Cyclotide MCoTI-I [J].

Austin, Jeffrey ;

Wang, Wan ;

Puttamadappa, Swamy ;

Shekhtman, Alexander ;

Camarero, Julio A. .

CHEMBIOCHEM, 2009, 10 (16) :2663-2670

[4] Structural classification of small, disulfide-rich protein domains [J].

Cheek, Sara ;

Krishna, S. Sri ;

Grishin, Nick V. .

JOURNAL OF MOLECULAR BIOLOGY, 2006, 359 (01) :215-237

[5] Molecular diversity and evolution of cystine knot toxins of the tarantula Chilobrachys jingzhao [J].

Chen, J. ;

Deng, M. ;

He, Q. ;

Meng, E. ;

Jiang, L. ;

Liao, Z. ;

Rong, M. ;

Liang, S. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2008, 65 (15) :2431-2444

[6] Squash inhibitors: From structural motifs to macrocyclic knottins [J].

Chiche, L ;

Heitz, A ;

Gelly, JC ;

Gracy, J ;

Chau, PTT ;

Ha, PT ;

Hernandez, JF ;

Le-Nguyen, D .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2004, 5 (05) :341-349

[7] Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design [J].

Clark, RJ ;

Daly, NL ;

Craik, DJ .

BIOCHEMICAL JOURNAL, 2006, 394 :85-93

[8] Thermal, chemical, and enzymatic stability of the cyclotide kalata B1: The importance of the cyclic cystine knot [J].

Colgrave, ML ;

Craik, DJ .

BIOCHEMISTRY, 2004, 43 (20) :5965-5975

[9] Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins [J].

Craik, David J. ;

Clark, Richard J. ;

Daly, Norelle L. .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2007, 16 (05) :595-604

[10]

Craik DJ, 2007, CURR OPIN DRUG DISC, V10, P176

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