The genetics of human systemic lupus erythematosus

被引：113

作者：

Harley, JB

Moser, KL

Gaffney, PM

Behrens, TW

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Med Res Fdn, Oklahoma City US Dept Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA

[2] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(98)80090-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Major advances in understanding the genetic foundation of systemic lupus erythematosus are in the offing. Genetic association studies suggest multiple effects that include those encoded by the HLA region, the genes for Fc gamma receptors and other genes such as that for the mannose-binding protein. Genome scan studies suggest many (at least twelve) genetic linkages with lupus. Identifying the genes linked with lupus is likely to require many years of concerted effort, as well as the availability and evaluation of much larger pedigree collections.

引用

页码：690 / 696

页数：7

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