The genetics of human systemic lupus erythematosus

被引：113

作者：

Harley, JB

Moser, KL

Gaffney, PM

Behrens, TW

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Med Res Fdn, Oklahoma City US Dept Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA

[2] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(98)80090-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Major advances in understanding the genetic foundation of systemic lupus erythematosus are in the offing. Genetic association studies suggest multiple effects that include those encoded by the HLA region, the genes for Fc gamma receptors and other genes such as that for the mannose-binding protein. Genome scan studies suggest many (at least twelve) genetic linkages with lupus. Identifying the genes linked with lupus is likely to require many years of concerted effort, as well as the availability and evaluation of much larger pedigree collections.

引用

页码：690 / 696

页数：7

共 66 条

[1]

ARNETT FC, 1997, DUBOIS LUPUS ERYTHEM, P77

[2] Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases [J].

Becker, KG ;

Simon, RM ;

Bailey-Wilson, JE ;

Freidlin, B ;

Biddison, WE ;

McFarland, HF ;

Trent, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :9979-9984

[3] Factor V:Q(506) mutation and anticardiolipin antibodies in systemic lupus erythematosus [J].

Bengtsson, A ;

Zoller, B ;

de Frutos, PG ;

Dahlback, B ;

Sturfelt, G .

LUPUS, 1996, 5 (06) :598-601

[4]

BIAS WB, 1986, AM J HUM GENET, V39, P584

[5] Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): No association with disease [J].

Bottto, M ;

Theodoridis, E ;

Thompson, EM ;

Beynon, HLC ;

Briggs, D ;

Isenberg, DA ;

Walport, MJ ;

Davies, KA .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 104 (02) :264-268

[6] Allelic markers close to prolactin are associated with HLA-DRB1 susceptibility alleles among women with rheumatoid arthritis and systemic lupus erythematosus [J].

Brennan, P ;

Hajeer, A ;

Ong, KR ;

Worthington, J ;

John, S ;

Thomson, W ;

Silman, A ;

Ollier, B .

ARTHRITIS AND RHEUMATISM, 1997, 40 (08) :1383-1386

[7] AN ABNORMALITY OF THE GENE THAT ENCODES NEUTROPHIL FC-RECEPTOR-III IN A PATIENT WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

CLARK, MR ;

LIU, L ;

CLARKSON, SB ;

ORY, PA ;

GOLDSTEIN, IM .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (01) :341-346

[8] Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection [J].

Cornall, RJ ;

Cyster, JG ;

Hibbs, ML ;

Dunn, AR ;

Otipoby, KL ;

Clark, EA ;

Goodnow, CC .

IMMUNITY, 1998, 8 (04) :497-508

[9]

DAVIES EJ, 1995, BRIT J RHEUMATOL, V34, P221

[10] MANNOSE-BINDING PROTEIN GENE POLYMORPHISM IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

DAVIES, EJ ;

SNOWDEN, N ;

HILLARBY, MC ;

CARTHY, D ;

GRENNAN, DM ;

THOMSON, W ;

OLLIER, WER .

ARTHRITIS AND RHEUMATISM, 1995, 38 (01) :110-114

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