MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated dendritic cells

被引：99

作者：

Chen, Ting ^{[1
]}

Li, Zhoubin ^{[3
]}

Tu, Jing ^{[3
]}

Zhu, Weiguo ^{[1
]}

Ge, Junhua ^{[1
]}

Zheng, Xiaoye ^{[1
]}

Yang, Lin ^{[1
]}

Pan, Xiaoping ^{[2
]}

Yan, Hui ^{[1
]}

Zhu, Jianhua ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Cardiothorac Surg, Hangzhou 310003, Zhejiang, Peoples R China

来源：

FEBS LETTERS | 2011年 / 585卷 / 04期

基金：

中国国家自然科学基金;

关键词：

MicroRNA-29a; Oxidized low density lipoprotein; Dendritic cell; Lipoprotein lipase; Immuno-inflammation; LIPOPROTEIN-LIPASE; KEY ROLE; HEART; MACROPHAGES; OXIDATION; GENES; PLAY; LDL;

D O I：

10.1016/j.febslet.2011.01.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether microRNAs are associated with DC immuno-inflammatory responses with oxidized low density lipoprotein (oxLDL) stimulation is not yet known. Our study aims to explore the link of miRNAs with lipid-overload and immuno-inflammatory mechanism for atherosclerosis. In DCs transfected with microRNA-29a mimics or inhibitors, we showed that microRNA-29a plays an important role in proinflammatory cytokine secretion and scavenger receptor expression upon oxLDL-treatment. Furthermore, we suggest an additional explanation for the mechanism of microRNA-29a regulation of its functional target, lipoprotein lipase. We conclude that microRNA-29a could regulate proinflammatory cytokine secretion and scavenger receptor expression by targeting lipoprotein lipase in oxLDL-stimulated dendritic cells. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：657 / 663

页数：7

共 32 条

[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].