Immune mechanisms in atherosclerosis

被引：656

作者：

Hansson, GK ^{[1
]}

机构：

[1] Karolinska Hosp, Karolinska Inst, Ctr Mol Med, SE-17176 Stockholm, Sweden

[2] Karolinska Hosp, Karolinska Inst, Dept Med, SE-17176 Stockholm, Sweden

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2001年 / 21卷 / 12期

关键词：

atherosclerosis; pathophysiology; cell biology; cytokines;

D O I：

10.1161/hq1201.100220

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis consist of macrophages and T cells. Unstable plaques are particularly rich in activated immune cells, suggesting that they may initiate plaque activation. We have seen a rapid increase in the understanding of the mechanisms that govern the recruitment, differentiation, and activation of immune cells in atherosclerosis. Experimental research has identified several candidate antigens, and there are encouraging data suggesting that immune modulation as well as immunization can reduce the progression of the disease. This review provides an overview of our current understanding of the role of immune mechanisms in atherosclerosis.

引用

页码：1876 / 1890

页数：15

共 231 条

[1] Chlamydia pneumoniae does not increase atherosclerosis in the aortic root of apolipoprotein E-deficient mice [J].

Aalto-Setälä, K ;

Laitinen, K ;

Erkkilä, L ;

Leinonen, M ;

Jauhiainen, M ;

Ehnholm, C ;

Tamminen, M ;

Puolakkainen, M ;

Penttilä, I ;

Saikku, P .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (04) :578-584

[2]

Abraham R, 1997, J IMMUNOL, V158, P4029

[3] Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits [J].

Ameli, S ;

HultgardhNilsson, A ;

Regnstrom, J ;

Calara, F ;

Yano, J ;

Cercek, B ;

Shah, PK ;

Nilsson, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (08) :1074-1079

[4] CYTOKINES AND GROWTH-FACTORS POSITIVELY AND NEGATIVELY REGULATE INTERSTITIAL COLLAGEN GENE-EXPRESSION IN HUMAN VASCULAR SMOOTH-MUSCLE CELLS [J].

AMENTO, EP ;

EHSANI, N ;

PALMER, H ;

LIBBY, P .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1223-1230

[5]

AMMAN V, 1995, THROMB RES, V77, P431

[6] Eta-1 (osteopontin): An early component of type-1 (cell-mediated) immunity [J].

Ashkar, S ;

Weber, GF ;

Panoutsakopoulou, V ;

Sanchirico, ME ;

Jansson, M ;

Zawaideh, S ;

Rittling, SR ;

Denhardt, DT ;

Glimcher, MJ ;

Cantor, H .

SCIENCE, 2000, 287 (5454) :860-864

[7] DETECTION AND LOCALIZATION OF TUMOR NECROSIS FACTOR IN HUMAN ATHEROMA [J].

BARATH, P ;

FISHBEIN, MC ;

CAO, J ;

BERENSON, J ;

HELFANT, RH ;

FORRESTER, JS .

AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (05) :297-302

[8] The structure of the T cell antigen receptor [J].

Bentley, GA ;

Mariuzza, RA .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :563-590

[9] PATIENTS WITH EARLY-ONSET PERIPHERAL VASCULAR-DISEASE HAVE INCREASED LEVELS OF AUTOANTIBODIES AGAINST OXIDIZED LDL [J].

BERGMARK, C ;

WU, R ;

DEFAIRE, U ;

LEFVERT, AK ;

SWEDENBORG, J .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1995, 15 (04) :441-445

[10] PURIFICATION OF CACHECTIN, A LIPOPROTEIN-LIPASE SUPPRESSING HORMONE SECRETED BY ENDOTOXIN-INDUCED RAW 264.7 CELLS [J].

BEUTLER, B ;

MAHONEY, J ;

LETRANG, N ;

PEKALA, P ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 161 (05) :984-995

← 1 2 3 4 5 6 7 8 9 10 →