The Toll-receptor family and central of innate immunity

被引：548

作者：

Kopp, EB ^{[1
]}

Medzhitov, R ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)80003-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor kappa B may represent the most ancient host defense system found in mammals, insects and plants.

引用

页码：13 / 18

页数：6

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