The cloning and characterization of human MyD88: A member of an IL-1 receptor related family

被引：115

作者：

Bonnert, TP

Garka, KE

Parnet, P

Sonoda, G

Testa, JR

Sims, JE

机构：

[1] IMMUNEX RES & DEV CORP,SEATTLE,WA 98101

[2] FOX CHASE CANC CTR,PHILADELPHIA,PA 19111

来源：

FEBS LETTERS | 1997年 / 402卷 / 01期

关键词：

interleukin; 1; receptor; death-domain; chromosome; 3p;

D O I：

10.1016/S0014-5793(96)01506-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Murine MyD88, an RNA with homology both to the interleukin-1 receptor signaling domain and to 'death-domains', is rapidly upregulated during differentiation of the myeloleukemic cell line M1, We have cloned the human homologue of murine MyD88 and re-evaluated the murine sequence. The open reading frame for both species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino acids longer than originally published, Human MyD88 cDNA is encoded by 5 exons, and maps to chromosome 3p21.3-p22 by fluorescence in situ hybridination (FISH), Overexpression of the death domain region leads to transcriptional activation of the IL-8 promoter.

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页码：81 / 84

页数：4

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