THE DEATH DOMAIN MOTIF FOUND IN FAS (APO-1) AND TNF RECEPTOR IS PRESENT IN PROTEINS INVOLVED IN APOPTOSIS AND AXONAL GUIDANCE

被引：103

作者：

HOFMANN, K

TSCHOPP, J

机构：

[1] UNIV LAUSANNE,INST BIOCHEM,CH-1066 EPALINGES,SWITZERLAND

[2] UNIV LAUSANNE,SWISS INST CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

FEBS LETTERS | 1995年 / 371卷 / 03期

关键词：

FAS; APO-1; TNF RECEPTOR; DEATH DOMAIN; APOPTOSIS; NEURON GUIDANCE; REAPER; RETINOBLASTOMA; UNC; ANKYRIN;

D O I：

10.1016/0014-5793(95)00931-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain, Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.

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页码：321 / 323

页数：3

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