Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat

被引：104

作者：

Cobbs, CS

Chen, J

Greenberg, DA

Graham, SH

机构：

[1] Univ Alabama Birmingham, Dept Neurosurg, Birmingham, AL USA

[2] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[3] Univ Pittsburgh, Dept Neurobiol, Pittsburgh, PA 15260 USA

[4] Dept Vet Affairs Med Ctr, Neurol Serv 127, Pittsburgh, PA USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

vascular endothelial growth factor; stroke; middle cerebral artery occlusion; border zone; edema; angiogenesis;

D O I：

10.1016/S0304-3940(98)00377-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vascular endothelial growth factor (VEGF) has been implicated in hypoxia-induced angiogenesis in tumors and ischemia. We examined VEGF mRNA and protein expression after occlusion of the middle cerebral artery (MCA) in rats. VEGF mRNA expression studied by in situ hybridization was increased in the ischemic border zone 24 h after 30, 60 or 120 min of focal cerebral ischemia. VEGF protein expression measured by Western blots was also increased in this region 24 and 48 h after ischemia, and VEGF immunocytochemistry localized this increased expression to astroglia. Thus, VEGF is induced after focal cerebral ischemia and could have a role in pathophysiology and recovery in the ischemic border zone. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：79 / 82

页数：4

共 14 条

[1] ANGIOGENIC-INDUCED ENHANCEMENT OF COLLATERAL BLOOD-FLOW TO ISCHEMIC MYOCARDIUM BY VASCULAR ENDOTHELIAL GROWTH-FACTOR IN DOGS [J].