AMINO-ACID AND CDNA SEQUENCES OF A VASCULAR ENDOTHELIAL-CELL MITOGEN THAT IS HOMOLOGOUS TO PLATELET-DERIVED GROWTH-FACTOR

被引：377

作者：

CONN, G ^{[1
]}

BAYNE, ML ^{[1
]}

SODERMAN, DD ^{[1
]}

KWOK, PW ^{[1
]}

SULLIVAN, KA ^{[1
]}

PALISI, TM ^{[1
]}

HOPE, DA ^{[1
]}

THOMAS, KA ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,DEPT BIOCHEM,ROOM 80W-243,POB 2000,RAHWAY,NJ 07065

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 07期

关键词：

cancer; evolution; neurobiology; protein growth factor;

D O I：

10.1073/pnas.87.7.2628

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis.

引用

页码：2628 / 2632

页数：5

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