Epigenetic mechanisms in Alzheimer's disease

被引：188

作者：

Mastroeni, Diego ^{[1
]}

Grover, Andrew ^{[1
]}

Delvaux, Elaine ^{[1
]}

Whiteside, Charisse ^{[1
]}

Coleman, Paul D. ^{[1
]}

Rogers, Joseph ^{[1
]}

机构：

[1] Banner Sun Hlth Res Inst, Sun City, AZ 85372 USA

来源：

NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 07期

关键词：

Epigenetics; DNA methylation; Histone acetylation; rDNA; miRNA; Genetics; Gene expression; Amyloid beta peptide; Inflammation; Oxidative stress; Cell cycle; HISTONE DEACETYLASE INHIBITORS; PRECURSOR PROTEIN GENE; BRAIN S-ADENOSYLMETHIONINE; REGULATES MEMORY FORMATION; GENOME-WIDE ASSOCIATION; AUTOPSY HUMAN CORTEX; DNA METHYLATION; CELL-CYCLE; NERVOUS-SYSTEM; MOUSE MODEL;

D O I：

10.1016/j.neurobiolaging.2010.08.017

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways. Although previous epigenetic research has focused primarily on dividing cells, particularly in cancer, recent studies have shown rapid, dynamic, and persistent epigenetic modifications in neurons that have significant neuroendocrine, neurophysiologic, and neurodegenerative consequences. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and Alzheimer's disease (AD). Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1161 / 1180

页数：20

共 204 条

[1] Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].