The emerging role of epigenetics in cellular and organismal aging

被引：66

作者：

Bandyopadhyay, D

Medrano, EE

机构：

[1] Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2003年 / 38卷 / 11-12期

基金：

美国国家卫生研究院;

关键词：

chromatin; chromatin modifiers; DNA-methylation; histone methylation; histone acetylation;

D O I：

10.1016/j.exger.2003.09.009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Genome modifications resulting from epigenetic changes appear to play a critical role in the development and/or progression of cancer. Scatter experimental evidence suggests that epigenetic changes could also be critical determinants of cellular senescence and organismal aging. Here we review the current evidence and discuss how imbalances in chromatin remodelers might trigger irreversible growth arrest in proliferating cells and tissues. Experimental data using drugs that target specific chromatin remodeling enzymes suggest that such approach could lead to the development of novel therapeutic modalities for the prevention or amelioration of some age-related dysfunctions. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1299 / 1307

页数：9

共 101 条

[1] CBP/p300 histone acetyl-transferase activity is important for the G1/S transition [J].