Signaling by Eph receptors and their ephrin ligands

被引：125

作者：

Brückner, K ^{[1
]}

Klein, R ^{[1
]}

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(98)80064-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

What are the mechanisms by which Eph receptor tyrosine kinases guide axons and migrating cells? Recent results show that Eph receptors bind some of the well-known effector molecules that are implicated in the organization of the actin cytoskeleton; moreover, biochemical and genetic evidence suggests a signaling role for transmembrane ephrin ligands in axon pathfinding.

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页码：375 / 382

页数：8

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