Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice

被引：51

作者：

Kilic, E ^{[1
]}

Hermann, DM ^{[1
]}

Hossmann, KA ^{[1
]}

机构：

[1] Max Planck Inst Neurol Forsch, D-50931 Cologne, Germany

来源：

NEUROREPORT | 1999年 / 10卷 / 01期

关键词：

blood flow; brain edema; focal ischemia; neurological score; neurotoxicity; tissue plasminogen activator (tPA); vital staining;

D O I：

10.1097/00001756-199901180-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IT has been suggested that tissue plasminogen activator (tPA), which is widely used for the thrombolytic treatment of stroke, exhibits neurotoxic side effects. To test this hypothesis, mice exposed to 90 min nonthrombotic middle cerebral artery thread occlusion were treated with 10 mg/kg recombinant tPA (rt-PA) at 15 min after the onset of vascular occlusion. Measurements of blood flow, infarct volume, brain swelling and neurological performance revealed faster recirculation and a significant reduction of ischemic injury in rt-PA-treated animals. These data are at variance with previous reports on tPA neurotoxicity and demonstrate, on the contrary, that tPA protects the brain even after non-thrombotic vascular occlusion. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：107 / 111

页数：5

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