Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension

被引:198
作者
Li, Qiang
Youn, Ji-Youn
Cai, Hua [1 ,2 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Div Mol Med, Dept Anesthesiol,Cardiovasc Res Labs, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Cardiol, Dept Med,Cardiovasc Res Labs, Los Angeles, CA 90095 USA
关键词
endothelial dysfunction; endothelial nitric oxide synthase; endothelial nitric oxide synthase uncoupling; hypertension; nicotinamide adenine dinucleotide phosphate oxidase; nitric oxide; oxidative stress; tetrahydrobiopterin; PROTEIN-KINASE-C; NADPH-OXIDASE; OXIDATIVE STRESS; ANGIOTENSIN-II; L-ARGININE; ASYMMETRIC DIMETHYLARGININE; DEOXYCORTICOSTERONE ACETATE; MESENTERIC-ARTERIES; ASCORBIC-ACID; DIHYDROFOLATE-REDUCTASE;
D O I
10.1097/HJH.0000000000000587
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension. The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of nitric oxide within the endothelium. Loss of eNOS cofactor tetrahydrobiopterin to initial increase in oxidative stress leads to uncoupling of eNOS, in which the enzyme produces superoxide anion rather than nitric oxide, further substantiating oxidative stress to induce vascular pathogenesis. The current review focuses on recent advances on the molecular mechanisms and consequences of eNOS dysfunction in hypertension, and potential novel therapeutic strategies restoring eNOS function to treat hypertension.
引用
收藏
页码:1128 / 1136
页数:9
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