Abnormal somatosensory homunculus in dystonia of the hand

被引：271

作者：

Bara-Jimenez, W ^{[1
]}

Catalan, MJ ^{[1
]}

Hallett, M ^{[1
]}

Gerloff, C ^{[1
]}

机构：

[1] NINDS, Human Motor Control Sect, Med Neurol Branch, NIH, Bethesda, MD 20892 USA

来源：

ANNALS OF NEUROLOGY | 1998年 / 44卷 / 05期

关键词：

D O I：

10.1002/ana.410440520

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Abnormalities of the sensory system have been proposed as causative factors for dystonia By mapping the human cortical hand somatosensory area of 6 patients with focal dystonia of the hand, we found an abnormality of the normal homuncular organization of the finger representations in the primary somatosensory cortex (S1). Although a remote antecedent event or even a developmental anomaly cannot entirely be ruled out, our findings may support the concept that abnormal plasticity is involved in the development of dystonia.

引用

页码：828 / 831

页数：4

共 20 条

[1] PREOPERATIVE LOCALIZATION OF THE CENTRAL SULCUS BY DIPOLE SOURCE ANALYSIS OF EARLY SOMATOSENSORY-EVOKED POTENTIALS AND 3-DIMENSIONAL MAGNETIC-RESONANCE-IMAGING [J].

BUCHNER, H ;

ADAMS, L ;

KNEPPER, A ;

RUGER, R ;

LABORDE, G ;

GILSBACH, JM ;

LUDWIG, I ;

REUL, J ;

SCHERG, M .

JOURNAL OF NEUROSURGERY, 1994, 80 (05) :849-856

[2] SOMATOTOPY OF HUMAN HAND SOMATOSENSORY CORTEX REVEALED BY DIPOLE SOURCE ANALYSIS OF EARLY SOMATOSENSORY-EVOKED POTENTIALS AND 3D-NMR TOMOGRAPHY [J].

BUCHNER, H ;

ADAMS, L ;

MULLER, A ;

LUDWIG, I ;

KNEPPER, A ;

THRON, A ;

NIEMANN, K ;

SCHERG, M .

EVOKED POTENTIALS-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1995, 96 (02) :121-134

[3]

Buchner Helmut, 1995, Brain Topography, V8, P137, DOI 10.1007/BF01199777

[4] VALIDITY AND RELIABILITY OF A RATING-SCALE FOR THE PRIMARY TORSION DYSTONIAS [J].

BURKE, RE ;

FAHN, S ;

MARSDEN, CD ;

BRESSMAN, SB ;

MOSKOWITZ, C ;

FRIEDMAN, J .

NEUROLOGY, 1985, 35 (01) :73-77

[5] A primate genesis model of focal dystonia and repetitive strain injury .1. Learning-induced dedifferentiation of the representation of the hand in the primary somatosensory cortex in adult monkeys [J].

Byl, NN ;

Merzenich, MM ;

Jenkins, WM .

NEUROLOGY, 1996, 47 (02) :508-520

[6]

Cohen L G, 1993, Adv Neurol, V63, P187

[7] HAND CRAMPS - CLINICAL-FEATURES AND ELECTROMYOGRAPHIC PATTERNS IN A FOCAL DYSTONIA [J].

COHEN, LG ;

HALLETT, M .

NEUROLOGY, 1988, 38 (07) :1005-1012

[8] EEG localization accuracy improvements using realistically shaped head models [J].

Cuffin, BN .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1996, 43 (03) :299-303

[9] TOPOGRAPHY OF SCALP RECORDED POTENTIALS-EVOKED BY STIMULATION OF THE DIGITS [J].

DUFF, TA .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1980, 49 (5-6) :452-460

[10] PHANTOM-LIMB PAIN AS A PERCEPTUAL CORRELATE OF CORTICAL REORGANIZATION FOLLOWING ARM AMPUTATION [J].

FLOR, H ;

ELBERT, T ;

KNECHT, S ;

WIENBRUCH, C ;

PANTEV, C ;

BIRBAUMER, N ;

LARBIG, W ;

TAUB, E .

NATURE, 1995, 375 (6531) :482-484

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