Chemical modification of proteins by lipids in diabetes

被引：73

作者：

Baynes, JW

机构：

[1] Univ S Carolina, Grad Sci Res Ctr, Dept Chem & Biochem, Columbia, SC 29208 USA

[2] Univ S Carolina, Sch Med, Columbia, SC 29208 USA

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2003年 / 41卷 / 09期

关键词：

ELISA; glycation; glycoxidation; lipid peroxidation; lipoxidation;

D O I：

10.1515/CCLM.2003.179

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Advanced glycation and lipoxidation endproducts (AGE/ALE) increase in tissue proteins with age and at an accelerated rate in diabetes. This Review focuses on the nature and source of AGEs/ALEs and the factors affecting their formation in tissue and plasma proteins. Lipids are identified as an important source of chemical modification of proteins in diabetes, and the role of diabetes, dyslipidemia and renal disease in formation of AGEs/ALEs is reviewed. The article concludes with a discussion of ELISA assays for AGEs/ALEs and the merits of measuring AGEs/ALEs in the clinical laboratory.

引用

收藏

页码：1159 / 1165

页数：7

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