The Rotterdam Study: Objectives and design update

被引:302
作者
Hofman, Albert [1 ]
Breteler, Monique M. B.
van Duijn, Cornelia M.
Krestin, Gabriel P.
Pols, Huibert A.
Stricker, Bruno H. Ch.
Tiemeier, Henning
Uitterlinden, Andre G.
Vingerling, Johannes R.
Witteman, Jacqueline C. M.
机构
[1] Erasmus Sch Med, Dept Epidemiol & Biostat, Rotterdam, Netherlands
[2] Erasmus Sch Med, Dept Radiol, Rotterdam, Netherlands
[3] Erasmus Sch Med, Dept Internal Med, Rotterdam, Netherlands
[4] Erasmus Sch Med, Dept Ophthalmol, Rotterdam, Netherlands
关键词
Alzheimer disease; cohort study; dementia; diabetes; genome wide analysis; glaucoma; heart failure; macular degeneration; myocardial infarction; osteoporosis; Parkinson disease; pharmaco-epidemiology; stroke;
D O I
10.1007/s10654-007-9199-x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in the Netherlands. The study targets cardiovascular, neurological, ophthalmological and endocrine diseases. As of 2008 about 15,000 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in some 600 research articles and reports (see http://www.epib.nl/rotterdamstudy). This article gives the reasons for the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.
引用
收藏
页码:819 / 829
页数:11
相关论文
共 89 条
[61]   Vitamin E and depressive symptoms are not related. The Rotterdam Study [J].
Tiemeier, H ;
Hofman, A ;
Kiliaan, AJ ;
Meijer, J ;
Breteler, MMB .
JOURNAL OF AFFECTIVE DISORDERS, 2002, 72 (01) :79-83
[62]   Cerebral haemodynamics and depression in the elderly [J].
Tiemeier, H ;
Bakker, SLM ;
Hofman, A ;
Koudstaal, PJ ;
Breteler, MMB .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2002, 73 (01) :34-39
[63]   Vitamin B12, folate, and homocysteine in depression:: The Rotterdam study [J].
Tiemeier, H ;
van Tuiji, HR ;
Hofman, A ;
Meijer, J ;
Kiliaan, AJ ;
Breteler, MMB .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (12) :2099-2101
[64]   Association between genetic variation in the gene for insulin-like growth factor-I and low birthweight [J].
Vaessen, N ;
Janssen, JA ;
Heutink, P ;
Hofman, A ;
Lamberts, SWJ ;
Oostra, BA ;
Pols, HAP ;
van Duijn, CM .
LANCET, 2002, 359 (9311) :1036-1037
[65]   Sleep duration and hypertension are not associated in the elderly [J].
van den Berg, Julia F. ;
Tulen, Joke H. M. ;
Neven, Arie Knuistingh ;
Hofman, Albert ;
Miedema, Henk M. E. ;
Witteman, Jacqueline C. M. ;
Tiemeier, Henning .
HYPERTENSION, 2007, 50 (03) :585-589
[66]   Corticosteroids and the risk of atrial fibrillation [J].
van der Hooft, Cornelis S. ;
Heeringa, Jan ;
Brusselle, Guy G. ;
Hofman, Albert ;
Witteman, Jacqueline C. M. ;
Kingma, J. Herre ;
Sturkenboom, Miriam C. J. M. ;
Stricker, Bruno H. Ch. .
ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (09) :1016-1020
[67]   Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction - The Rotterdam study [J].
van der Meer, IM ;
Bots, ML ;
Hofman, A ;
del Sol, AI ;
van der Kuip, DAM ;
Witteman, JCM .
CIRCULATION, 2004, 109 (09) :1089-1094
[68]   Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement [J].
van Leeuwen, R ;
Vingerling, JR ;
Hofman, A ;
de Jong, PTVM ;
Stricker, BH .
BRITISH MEDICAL JOURNAL, 2003, 326 (7383) :255-256
[69]   Homocysteine levels and the risk of osteoporotic fracture [J].
van Meurs, JBJ ;
Dhonukshe-Rutten, RAM ;
Pluijm, SMF ;
van der Klift, M ;
de Jonge, R ;
Lindemans, J ;
de Groot, LCPGM ;
Hofman, A ;
Witteman, JCM ;
van Leeuwen, JPTM ;
Breteler, MMB ;
Lips, P ;
Pols, HAP ;
Uitterlinden, AG .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (20) :2033-2041
[70]   Association of 5′ estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk [J].
van Meurs, JBJ ;
Schuit, SCE ;
Weel, AEAM ;
van der Klift, M ;
Bergink, AP ;
Arp, PP ;
Colin, EM ;
Fang, Y ;
Hofman, A ;
van Duijn, CM ;
van Leeuwen, JPTM ;
Pols, HAP ;
Uitterlinden, AG .
HUMAN MOLECULAR GENETICS, 2003, 12 (14) :1745-1754