Apoptosis control by death and decoy receptors

被引：1122

作者：

Ashkenazi, A ^{[1
]}

Dixit, VM ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80034-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The death receptors Fas and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis upon engagement by their cognate death ligands. Recently, researchers have discovered several novel homologues of Fas and TNFR1: DR 3, 4, 5, and 6 function as death receptors that signal apoptosis, whereas DcR 1, 2, and 3 act as decoys that compete with specific death receptors for ligand binding. Further, mouse gene knockout studies have enabled researchers to delineate some of the signaling pathways that connect death receptors to the cell's apoptotic machinery.

引用

页码：255 / 260

页数：6

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