Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

被引：557

作者：

DegliEsposti, MA ^{[1
]}

Smolak, PJ ^{[1
]}

Walczak, H ^{[1
]}

Waugh, J ^{[1
]}

Huang, CP ^{[1
]}

DuBose, RF ^{[1
]}

Goodwin, RG ^{[1
]}

Smith, CA ^{[1
]}

机构：

[1] IMMUNEX RES & DEV CORP, DEPT MOL BIOL, SEATTLE, WA 98101 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1997年 / 186卷 / 07期

关键词：

D O I：

10.1084/jem.186.7.1165

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TRAIL-R3, a new member of the TRAIL receptor family, has been cloned and characterized. TRAIL-R3 encodes a 299 amino acid protein with 58 and 54% overall identity to TRAIL-R1 and -R2, respectively. Transient expression and quantitative binding studies show TRAIL-R3 to be a plasma membrane-bound protein capable of high affinity interaction with the TRAIL ligand. The TRAIL-R3 gene maps to human chromosome 8p22-21, clustered with the genes encoding two other TRAIL receptors. In contrast to TRAIL-R1 and -R2, this receptor shows restricted expression, with transcripts detectable only in peripheral blood lymphocytes and spleen. The structure of TRAIL-R3 is unique when compared to the other TRAIL receptors in that it lacks a cytoplasmic domain and appears to be glycosyl-phosphatidylinositol-linked. Moreover, unlike TRAIL-R1 and -R2, in a transient overexpression system TRAIL-R3 does not induce apoptosis.

引用

页码：1165 / 1170

页数：6

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