Autophagy in the pathogenesis of disease

被引：6407

作者：

Levine, Beth ^{[1
,2
]}

Kroemer, Guido ^{[3
,4
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[3] Univ Paris 11, Paris, France

[4] INSERM, U848, F-94805 Villejuif, France

来源：

CELL | 2008年 / 132卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.12.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.

引用

收藏

页码：27 / 42

页数：16

相关论文

共 101 条

[1] Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma [J].

Amaravadi, Ravi K. ;

Yu, Duonan ;

Lum, Julian J. ;

Bui, Thi ;

Christophorou, Maria A. ;

Evan, Gerard I. ;

Thomas-Tikhonenko, Andrei ;

Thompson, Craig B. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (02) :326-336

[2] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[3] Inclusion-body myositis -: A myodegenerative conformational disorder associated with Aβ, protein misfolding, and proteasome inhibition [J].

Askanas, V ;

Engel, WK .

NEUROLOGY, 2006, 66 :S39-S48

[4] SHORT-TERM STIMULATION BY PROPRANOLOL AND VERAPAMIL OF CARDIAC CELLULAR AUTOPHAGY [J].

BAHRO, M ;

PFEIFER, U .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1987, 19 (12) :1169-1178

[5] Autophagy in development and stress responses of plants [J].

Bassham, DC ;

Laporte, M ;

Marty, F ;

Moriyasu, Y ;

Ohsumi, Y ;

Olsen, LJ ;

Yoshimoto, K .

AUTOPHAGY, 2006, 2 (01) :2-11

[6] Gastroenterology 1 - Inflammatory bowel disease: cause and immunobiology [J].

Baumgart, Daniel C. ;

Carding, Simon R. .

LANCET, 2007, 369 (9573) :1627-1640

[7] Targets for antiageing drugs [J].

Bergamini, E .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2005, 9 (01) :77-82

[8] Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease [J].

Bolaños-Meade, J ;

Zhou, L ;

Hoke, A ;

Corse, A ;

Vogelsang, G ;

Wagner, KR .

AMERICAN JOURNAL OF HEMATOLOGY, 2005, 78 (04) :306-309

[9] Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis [J].

Cao, Yi ;

Espinola, Janice A. ;

Fossale, Elisa ;

Massey, Ashish C. ;

Cuervo, Ana Maria ;

MacDonald, Marcy E. ;

Cotman, Susan L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (29) :20483-20493

[10] DRAM, a p53-induced modulator of autophagy, is critical for apoptosis [J].

Crighton, Diane ;

Wilkinson, Simon ;

O'Prey, Jim ;

Syed, Nelofer ;

Smith, Paul ;

Harrison, Paul R. ;

Gasco, Milena ;

Garrone, Ornella ;

Crook, Tim ;

Ryan, Kevin M. .

CELL, 2006, 126 (01) :121-134

← 1 2 3 4 5 6 7 8 9 10 →