Hydroxychloroquine causes severe vacuolar myopathy in a patient with chronic graft-versus-host disease

被引：28

作者：

Bolaños-Meade, J

Zhou, L

Hoke, A

Corse, A

Vogelsang, G

Wagner, KR

机构：

[1] Johns Hopkins Univ Hosp, Dept Neurol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ Hosp, Dept Oncol, Baltimore, MD 21287 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2005年 / 78卷 / 04期

关键词：

graft-versus-host disease; hydroxychloroquine; vacuolar myopathy; myopathy;

D O I：

10.1002/ajh.20294

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 51-year-old man developed progressive debilitating limb and respiratory muscle weakness while undergoing treatment for chronic graft-versus-host disease secondary to allogeneic bone marrow transplant for mantle cell lymphoma. He had a normal serum creatine kinase level and acetylcholine receptor antibodies were negative. Electromyography showed a severe, nonirritable myopathy and a sensory motor axonal polyneuropathy. A muscle biopsy showed a necrotizing, vacuolar myopathy with many fibers containing autophagic and red-rimmed vacuoles, suggestive of an amphiphilic drug myopathy. The patient's strength and function improved significantly after discontinuation of hydroxychloroquine. (c) 2005 Wiley-Liss, Inc.

引用

页码：306 / 309

页数：4

共 18 条

[1] Antimalarial drugs inhibit phospholipase A2 activation and induction of interleukin 1β and tumor necrosis factor α in macrophages:: Implications for their mode of action in rheumatoid arthritis [J].