Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins

被引：150

作者：

Collin, M ^{[1
]}

Olsén, A ^{[1
]}

机构：

[1] Lund Univ, Dept Cell & Mol Biol, Sect Mol Pathogenesis, SE-22184 Lund, Sweden

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 11期

关键词：

D O I：

10.1128/IAI.69.11.7187-7189.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, Spell, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, Spell has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.

引用

页码：7187 / 7189

页数：3

共 25 条

[21] Recognition of IgG by Fcγ receptor -: The role of Fc glycosylation and the binding of peptide inhibitors [J].

Radaev, S ;

Sun, PD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) :16478-16483

[22] Cysteine protease secreted by Paragonimus westemani attenuates effector functions of human eosinophils stimulated with immunoglobulin G [J].

Shin, MH ;

Kita, H ;

Park, HY ;

Seoh, JY .

INFECTION AND IMMUNITY, 2001, 69 (03) :1599-1604

[23]

TARENTINO AL, 1994, METHOD ENZYMOL, V230, P44

[24] ELECTROPHORETIC TRANSFER OF PROTEINS FROM POLYACRYLAMIDE GELS TO NITROCELLULOSE SHEETS - PROCEDURE AND SOME APPLICATIONS [J].

TOWBIN, H ;

STAEHELIN, T ;

GORDON, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (09) :4350-4354

[25] Effect of group A streptococcal cysteine protease on invasion of epithelial cells [J].

Tsai, PJ ;

Kuo, CF ;

Lin, KY ;

Lin, YS ;

Lei, HY ;

Chen, FF ;

Wang, JR ;

Wu, JJ .

INFECTION AND IMMUNITY, 1998, 66 (04) :1460-1466

← 1 2 3 →