Regeneration of dorsal column axons after spinal cord injury in young rats

被引：23

作者：

Kikukawa, S

Kawaguchi, S ^{[1
]}

Mizoguchi, A

Ide, C

Koshinaga, M

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Integrat Brain Sci, Kyoto 6068501, Japan

[2] Kyoto Univ, Fac Med, Kyoto 6068501, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Anat & Neurobiol, Kyoto 6068501, Japan

[4] Nihon Univ, Sch Med, Dept Neurol Surg, Tokyo 1730032, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

spinal cord injury; axonal regeneration; dorsal column projections; transganglionic transport; dorsal root ganglia; chromatolysis; axonal environment;

D O I：

10.1016/S0304-3940(98)00406-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In contrast to previous reports denying the occurrence of axonal regeneration of the dorsal column (DC) projections, here we demonstrate for the first time that marked regeneration occurs spontaneously after transection in infant rats. Transection was made sharply so as to produce edema-free lesions without subsequent formation of either scars or cysts. Transganglionic labeling of axons revealed that regenerated axons ascended in the normal tract in a manner similar to normal projections as a tightly-packed fasciculus and terminated densely in the nucleus gracilis. The present study indicates that failure of regeneration of DC axons is due to neither intrinsic deficiency of regrowth potential nor global ly-inhospitable axonal environment but rather the local conditions of the lesion site. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：135 / 138

页数：4

共 19 条

[11] QUANTITATIVE STUDY OF MORPHOLOGICAL CHANGES ACCOMPANYING INITIATION AND PROGRESS OF MYELIN PRODUCTION IN DORSAL FUNICULUS OF RAT SPINAL CORD [J].