Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense

被引：680

作者：

Levine, B ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75330 USA

来源：

CELL | 2005年 / 120卷 / 02期

关键词：

D O I：

10.1016/j.cell.2005.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The eukaryotic cell uses an evolutionarily conserved lysosomal pathway of self-digestion (autophagy) for survival when extracellular nutrients are limited. In this issue of Cell, new evidence indicates that autophagy is used to for survival when intracellular nutrients are limited by growth factor deprivation (Lum et al., 2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy).

引用

页码：159 / 162

页数：4

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