Autophagy defends cells against invading group a Streptococcus

被引：952

作者：

Nakagawa, I

Amano, A

Mizushima, N

Yamamoto, A

Yamaguchi, H

Kamimoto, T

Nara, J

Funao, J

Nakata, M

Tsuda, K

Hamada, S

Yoshimori, T

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Oral & Mol Microbiol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Dent, Dept Oral Frontier Biol, Suita, Osaka 5650871, Japan

[3] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[4] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

[5] Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Bunkyo Ku, Tokyo 1138613, Japan

[6] Nagahama Inst Biosci & Technol, Fac Biosci, Dept Cell Biol, Nagahama, Shiga 5260829, Japan

[7] Natl Inst Genet, SOKENDAI, Dept Cell Genet, Mishima, Shizuoka 4118540, Japan

来源：

SCIENCE | 2004年 / 306卷 / 5698期

关键词：

D O I：

10.1126/science.1103966

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5(-/-) cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens.

引用

页码：1037 / 1040

页数：4

共 20 条

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