Caveolae: Mining little caves for new cancer targets

被引：224

作者：

Carver, LA ^{[1
]}

Schnitzer, JE ^{[1
]}

机构：

[1] Sidney Kimmel Canc Ctr, Div Vasc Biol & Angiogenesis, San Diego, CA 92121 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caveolae exist at cell surfaces as caveolin-coated invaginations that perform transport and signalling functions influencing cell growth, apoptosis, angiogenesis and transvascular exchange. Caveolin could constitute a key switch in tumour development through its function as a tumour suppressor and as a promoter of metastasis, chemoresistance and survival. Targeting of drugs and gene vectors to tissue-specific proteins in caveolae allows selective delivery into vascular endothelial cells in vivo and might even improve direct access to solid-tumour cells. Therefore, caveolae seem to be rich in potential targets for cancer imaging and therapeutics.

引用

页码：571 / 581

页数：11

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