Calcium signalling in lymphocyte activation and disease

被引：828

作者：

Feske, Stefan ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 09期

关键词：

D O I：

10.1038/nri2152

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Calcium signals in cells of the immune system participate in the regulation of cell differentiation, gene transcription and effector functions. An increase in intracellular levels of calcium ions (Ca2+) results from the engagement of immunoreceptors, such as the T-cell receptor, B-cell receptor and Fc receptors, as well as chemokine and co-stimulatory receptors. The major pathway that induces an increase in intracellular Ca2+ levels in lymphocytes is through store-operated calcium entry (SOCE) and calcium-release activated calcium ( CRAC) channels. This Review focuses on the role of Ca2+ signals in lymphocyte functions, the signalling pathways leading to Ca2+ influx, the function of the recently discovered regulators of Ca2+ influx (STIM and ORAI), and the relationship between Ca2+ signals and diseases of the immune system.

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页码：690 / 702

页数：13

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