Telomere maintenance mechanisms and cellular immortalization

被引：151

作者：

Colgin, LM ^{[1
]}

Reddel, RR ^{[1
]}

机构：

[1] Childrens Med Res Inst, Westmead, NSW 2145, Australia

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-437X(99)80014-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Immortal cell populations are able to proliferate indefinitely. Immortalization is associated with activation of processes that compensate for the telomeric shortening that accompanies cell division in normal somatic cells. In many immortal cell lines, telomere maintenance is provided by the action of the ribonucleoprotein enzyme complex, telomerase. Some immortal cell lines have undetectable or very low levels of telomerase activity and there is evidence that these cells maintain their telomeres by an alternative mechanism.

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收藏

页码：97 / 103

页数：7

相关论文

共 101 条

[31] Yeast Ku as a regulator of chromosomal DNA end structure [J].

Gravel, S ;

Larrivée, M ;

Labrecque, P ;

Wellinger, RJ .

SCIENCE, 1998, 280 (5364) :741-744

[32] Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation [J].

Greenberg, RA ;

Allsopp, RC ;

Chin, L ;

Morin, GB ;

DePinho, RA .

ONCOGENE, 1998, 16 (13) :1723-1730

[33] Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties [J].

Greene, EC ;

Shippen, DE .

GENES & DEVELOPMENT, 1998, 12 (18) :2921-2931

[34] IDENTIFICATION OF A SPECIFIC TELOMERE TERMINAL TRANSFERASE-ACTIVITY IN TETRAHYMENA EXTRACTS [J].

GREIDER, CW ;

BLACKBURN, EH .

CELL, 1985, 43 (02) :405-413

[35] TRF1 promotes parallel pairing of telomeric tracts in vitro [J].

Griffith, J ;

Bianchi, A ;

de Lange, T .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 278 (01) :79-88

[36] Telomerase activity in the regenerative basal layer of the epidermis in human skin and in immortal and carcinoma-derived skin keratinocytes [J].

HarleBachor, C ;

Boukamp, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6476-6481

[37] TELOMERE LOSS - MITOTIC CLOCK OR GENETIC TIME BOMB [J].

HARLEY, CB .

MUTATION RESEARCH, 1991, 256 (2-6) :271-282

[38] Human telomerase contains evolutionarily conserved catalytic and structural subunits [J].

Harrington, L ;

Zhou, W ;

McPhail, T ;

Oulton, R ;

Yeung, DSK ;

Mar, V ;

Bass, MB ;

Robinson, MO .

GENES & DEVELOPMENT, 1997, 11 (23) :3109-3115

[39] A mammalian telomerase-associated protein [J].

Harrington, L ;

McPhail, T ;

Mar, V ;

Zhou, W ;

Oulton, R ;

Bass, MB ;

Arruda, I ;

Robinson, MO .

SCIENCE, 1997, 275 (5302) :973-977

[40] In situ analysis of changes in telomere size during replicative aging and cell transformation [J].

Henderson, S ;

Allsopp, R ;

Spector, D ;

Wang, SS ;

Harley, C .

JOURNAL OF CELL BIOLOGY, 1996, 134 (01) :1-12

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