Telomerase activation - one step on the road to cancer?

被引：76

作者：

Greider, CW ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

来源：

TRENDS IN GENETICS | 1999年 / 15卷 / 03期

关键词：

D O I：

10.1016/S0168-9525(98)01681-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ever since the discovery that telomeres are short in cancer cells and telomerase is activated in immortal cells, telomerase has been an oncogene wannabe. Oncogenes have been the glamour genes of molecular biology for 20 years, garnering flashy headlines and name recognition. More recently, tumor-suppressor genes have joined oncogenes on center stage. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, and that TERT cooperates with HPV E7 in cell immortalization. This evidence now supports the placement of telomerase among the cancer gene elite.

引用

页码：109 / 112

页数：4

共 68 条

[51]

Ogoshi M, 1997, J IMMUNOL, V158, P622

[52] Alteration of telomerase activity associated with development and extension of epithelial ovarian cancer [J].

Oishi, T ;

Kigawa, J ;

Minagawa, Y ;

Shimada, M ;

Takahashi, M ;

Terakawa, N .

OBSTETRICS AND GYNECOLOGY, 1998, 91 (04) :568-571

[53] ALTERED CELL-CYCLE REGULATION IN THE LENS OF HPV-16 E6 OR E7 TRANSGENIC MICE - IMPLICATIONS FOR TUMOR-SUPPRESSOR GENE-FUNCTION IN DEVELOPMENT [J].

PAN, HC ;

GRIEP, AE .

GENES & DEVELOPMENT, 1994, 8 (11) :1285-1299

[54] MULTIPLE ARRANGEMENTS OF VIRAL-DNA AND AN ACTIVATED HOST ONCOGENE IN BURSAL LYMPHOMAS [J].

PAYNE, GS ;

BISHOP, JM ;

VARMUS, HE .

NATURE, 1982, 295 (5846) :209-214

[55] ANTIBODIES TO HUMAN C-MYC ONCOGENE PRODUCT - EVIDENCE OF AN EVOLUTIONARILY CONSERVED PROTEIN-INDUCED DURING CELL-PROLIFERATION [J].

PERSSON, H ;

HENNIGHAUSEN, L ;

TAUB, R ;

DEGRADO, W ;

LEDER, P .

SCIENCE, 1984, 225 (4663) :687-693

[56] SPATIAL AND TEMPORAL PATTERN OF CELLULAR MYC ONCOGENE EXPRESSION IN DEVELOPING HUMAN-PLACENTA - IMPLICATIONS FOR EMBRYONIC-CELL PROLIFERATION [J].

PFEIFEROHLSSON, S ;

GOUSTIN, AS ;

RYDNERT, J ;

WAHLSTROM, T ;

BJERSING, L ;

STEHELIN, D ;

OHLSSON, R .

CELL, 1984, 38 (02) :585-596

[57] REGULATION OF C-MYC MESSENGER-RNA LEVELS IN NORMAL HUMAN-LYMPHOCYTES BY MODULATORS OF CELL-PROLIFERATION [J].

REED, JC ;

NOWELL, PC ;

HOOVER, RG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) :4221-4224

[58] THE HPV-16 E6 AND E6-AP COMPLEX FUNCTIONS AS A UBIQUITIN-PROTEIN LIGASE IN THE UBIQUITINATION OF P53 [J].

SCHEFFNER, M ;

HUIBREGTSE, JM ;

VIERSTRA, RD ;

HOWLEY, PM .

CELL, 1993, 75 (03) :495-505

[59]

SHAY JW, 1993, ONCOGENE, V8, P1407

[60] STUDIES ON THE MECHANISMS INVOLVED IN MULTISTAGE CARCINOGENESIS IN MOUSE SKIN [J].

SLAGA, TJ ;

FISCHER, SM ;

WEEKS, CE ;

KLEINSZANTO, AJP ;

REINERS, J .

JOURNAL OF CELLULAR BIOCHEMISTRY, 1982, 18 (01) :99-119

← 1 2 3 4 5 6 7 →