Vitamin D and autoimmunity: New aetiological and therapeutic considerations

被引：481

作者：

Arnson, Yoav ^{[1
]}

Amital, Howard ^{[1
]}

Shoenfeld, Yehuda ^{[1
]}

机构：

[1] Meir Med Ctr, Dept Med, IL-95847 Saba, Israel

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2007年 / 66卷 / 09期

关键词：

D O I：

10.1136/ard.2007.069831

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vitamin D is frequently prescribed by rheumatologists to prevent and treat osteoporosis. Several observations have shown that vitamin D inhibits proinflammatory processes by suppressing the enhanced activity of immune cells that take part in the autoimmune reaction. Moreover, recent evidence strongly suggests that vitamin D supplementation may be therapeutically beneficial, particularly for Th1-mediated autoimmune disorders. Some reports imply that vitamin D may even be preventive in certain disorders such as multiple sclerosis and diabetes type 1. It seems that vitamin D has crossed the boundaries of calcium metabolism and has become a significant factor in a number of physiological functions, specifically as a biological inhibitor of inflammatory hyperactivity.

引用

页码：1137 / 1142

页数：6

共 100 条

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