Vitamin D and autoimmunity: New aetiological and therapeutic considerations

被引:481
作者
Arnson, Yoav [1 ]
Amital, Howard [1 ]
Shoenfeld, Yehuda [1 ]
机构
[1] Meir Med Ctr, Dept Med, IL-95847 Saba, Israel
关键词
D O I
10.1136/ard.2007.069831
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vitamin D is frequently prescribed by rheumatologists to prevent and treat osteoporosis. Several observations have shown that vitamin D inhibits proinflammatory processes by suppressing the enhanced activity of immune cells that take part in the autoimmune reaction. Moreover, recent evidence strongly suggests that vitamin D supplementation may be therapeutically beneficial, particularly for Th1-mediated autoimmune disorders. Some reports imply that vitamin D may even be preventive in certain disorders such as multiple sclerosis and diabetes type 1. It seems that vitamin D has crossed the boundaries of calcium metabolism and has become a significant factor in a number of physiological functions, specifically as a biological inhibitor of inflammatory hyperactivity.
引用
收藏
页码:1137 / 1142
页数:6
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