Role of Jak kinases and STATS in cytokine signal transduction

被引：202

作者：

Leonard, WJ ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2001年 / 73卷 / 03期

关键词：

Jak kinase; STAT; cytokine; receptor; signaling;

D O I：

10.1007/BF02981951

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Janus family tyrosine kinase-signal transducer and activator of transcription (Jak-STAT) signaling pathway is broadly used by interferons and type I cytokines. These cytokines and interferons activate Janus family tyrosine kinases (Jak kinases), which in turn phosphorylate and thereby activate STAT proteins. Before activation, STAT proteins are cytosolic proteins. after activation, however. they are translocated to the nucleus where they function as transcription factors. This review summarizes salient features of the Jak-STAT pathway and focuses on the functional role of the different Jak kinases and STATs in vivo. (C) 2001 The Japanese Society of Hematology.

引用

收藏

页码：271 / 277

页数：7

相关论文

共 50 条

[41] Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression [J].

Udy, GB ;

Towers, RP ;

Snell, RG ;

Wilkins, RJ ;

Park, SH ;

Ram, PA ;

Waxman, DJ ;

Davey, HW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (14) :7239-7244

[42] Structure of the amino-terminal protein interaction domain of STAT-4 [J].

Vinkemeier, U ;

Moarefi, I ;

Darnell, JE ;

Kuriyan, J .

SCIENCE, 1998, 279 (5353) :1048-1052

[43] DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: Interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites [J].

Vinkemeier, U ;

Cohen, SL ;

Moarefi, I ;

Chait, BT ;

Kuriyan, J ;

Darnell, JE .

EMBO JOURNAL, 1996, 15 (20) :5616-5626

[44]

WeberNordt RM, 1996, BLOOD, V88, P809

[45] JAK2 ASSOCIATES WITH THE ERYTHROPOIETIN RECEPTOR AND IS TYROSINE-PHOSPHORYLATED AND ACTIVATED FOLLOWING STIMULATION WITH ERYTHROPOIETIN [J].

WITTHUHN, BA ;

QUELLE, FW ;

SILVENNOINEN, O ;

YI, TL ;

TANG, B ;

MIURA, O ;

IHLE, JN .

CELL, 1993, 74 (02) :227-236

[46] Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain [J].

Xu, XA ;

Sun, YL ;

Hoey, T .

SCIENCE, 1996, 273 (5276) :794-797

[47]

YASUKAWA H, 1999, CURR BIOL, V9, pR899

[48] ENHANCED DNA-BINDING ACTIVITY OF A STAT3-RELATED PROTEIN IN CELLS TRANSFORMED BY THE SRC ONCOPROTEIN [J].

YU, CL ;

MEYER, DJ ;

CAMPBELL, GS ;

LARNER, AC ;

CARTERSU, C ;

SCHWARTZ, J ;

JOVE, R .

SCIENCE, 1995, 269 (5220) :81-83

[49] Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling [J].

Zhang, JJ ;

Vinkemeier, U ;

Gu, W ;

Chakravarti, D ;

Horvath, CM ;

Darnell, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) :15092-15096

[50]

2000, ONCOGENE, V91, P2466

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