A gene expression map for Caenorhabditis elegans

被引:509
作者
Kim, SK [1 ]
Lund, J
Kiraly, M
Duke, K
Jiang, M
Stuart, JM
Eizinger, A
Wylie, BN
Davidson, GS
机构
[1] Stanford Univ, Sch Med, Dept Dev Biol & Genet, Stanford, CA 94305 USA
[2] Stanford Med Informat, Stanford, CA 94305 USA
[3] Sandia Natl Labs, Computat Comp & Math Ctr, Albuquerque, NM 87185 USA
关键词
D O I
10.1126/science.1061603
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery toot to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in mates and sperm caused by specific transposons).
引用
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页码:2087 / 2092
页数:6
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