Evolutionary dynamics of non-coding sequences within the class II region of the human MHC

被引：72

作者：

Beck, S ^{[1
]}

Abdulla, S ^{[1
]}

Alderton, RP ^{[1
]}

Glynne, RJ ^{[1
]}

Gut, IG ^{[1
]}

Hosking, LK ^{[1
]}

Jackson, A ^{[1
]}

Kelly, A ^{[1
]}

Newell, WR ^{[1
]}

Sanseau, P ^{[1
]}

Radley, E ^{[1
]}

Thorpe, KL ^{[1
]}

Trowsdale, J ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,HUMAN IMMUNOGENET LAB,LONDON WC2A 3PX,ENGLAND

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1996年 / 255卷 / 01期

关键词：

evolution; repeat analysis; pseudogenes; isochores; natural polymorphism;

D O I：

10.1006/jmbi.1996.0001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

About 40% (350 kb) of the human MHC class II region has been sequenced and a coordinated effort to sequence the entire MHC is underway. In addition to the coding information (22 genes/pseudogenes), the non-coding sequences reveal novel information on the organisation and evolution of the MHC as demonstrated here by the example of a 200 kb contig that has been analysed for local and global features. In conjunction with cross-species comparisons, our results present new evidence on the structure of isochores, the evolutionary dynamics of repeat-mediated recombination and its effect on certain MHC encoded genes, and a higher than average degree of natural polymorphism that has implications for sequencing the human genome. We also report the finding of a class I-related pseudogene (HLA-ZI) in the middle of the class II region, which provides the first direct evidence for DNA exchange between these two related regions in man. (C) 1996 Academic Press Limited

引用

页码：1 / 13

页数：13

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