Isoprenoid biosynthesis. Metabolite profiling of peppermint oil gland secretory cells and application to herbicide target analysis

被引：55

作者：

Lange, BM ^{[1
]}

Ketchum, REB ^{[1
]}

Croteau, RB ^{[1
]}

机构：

[1] Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA

来源：

PLANT PHYSIOLOGY | 2001年 / 127卷 / 01期

关键词：

D O I：

10.1104/pp.127.1.305

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two independent pathways operate in plants for the synthesis of isopentenyl diphosphate and dimethylallyl diphosphate, the central intermediates in the biosynthesis of all isoprenoids. The mevalonate pathway is present in the cytosol, whereas the recently discovered mevalonate-independent pathway is localized to plastids. We have used isolated peppermint (Mentha piperita) oil gland secretory cells as an experimental model system to study the effects of the herbicides fosmido-mycin, phosphonothrixin, methyl viologen, benzyl viologen, clomazone, 2-(dimethylamino)ethyl diphosphate, alendronate, and pamidronate on the pools of metabolites related to monoterpene biosynthesis via the mevalonate-independent pathway. A newly developed isolation protocol for polar metabolites together with an improved separation and detection method based on liquid chromatography-mass spectrometry have allowed assessment of the enzyme targets for a number of these herbicides.

引用

页码：305 / 314

页数：10

共 56 条

[41]

SANDMANN G, 1986, Z NATURFORSCH C, V41, P729

[42] INHIBITION OF BACTERIAL ISOPRENOID SYNTHESIS BY FOSMIDOMYCIN, A PHOSPHONIC ACID-CONTAINING ANTIBIOTIC [J].

SHIGI, Y .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 24 (02) :131-145

[43]

SOLER E, 1992, PLANTA, V187, P171, DOI 10.1007/BF00201934

[44] Studies on the nonmevalonate pathway:: formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate from 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol [J].

Takagi, M ;

Kuzuyama, T ;

Kaneda, K ;

Watanabe, H ;

Dairi, T ;

Seto, H .

TETRAHEDRON LETTERS, 2000, 41 (18) :3395-3398

[45] PHOSPHONOTHRIXIN, A NOVEL HERBICIDAL ANTIBIOTIC PRODUCED BY SACCHAROTHRIX SP ST-888 .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES [J].

TAKAHASHI, E ;

KIMURA, T ;

NAKAMURA, K ;

ARAHIRA, M ;

IIDA, M .

JOURNAL OF ANTIBIOTICS, 1995, 48 (10) :1124-1129

[46]

Thiellement H, 1999, ELECTROPHORESIS, V20, P2013, DOI 10.1002/(SICI)1522-2683(19990701)20:10&lt

[47]

2013::AID-ELPS2013&gt

[48]

3.0.CO

[49]

2-#

[50] Multiple independent defective Suppressor-mutator transposon insertions in Arabidopsis:: A tool for functional genomics [J].

Tissier, AF ;

Marillonnet, S ;

Klimyuk, V ;

Patel, K ;

Torres, MA ;

Murphy, G ;

Jones, JDG .

PLANT CELL, 1999, 11 (10) :1841-1852

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