Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

被引：490

作者：

Birchmeier, C

Gherardi, E

机构：

[1] Max Delbruck Ctr Mol Med, Dept Med Genet, D-13122 Berlin, Germany

[2] Univ Cambridge, Ctr Mrc, Dept Oncol, Growth Factors Grp, Cambridge CB2 2QH, England

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0962-8924(98)01359-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A number of developmental processes that involve cell migration, growth or morphogenesis depend on extracellular signals. A molecule that provides such signals, known as hepatocyte growth factor/scatter factor (HGF/SF), has attracted considerable interest in recent years because of its distinct structure, mechanism of activation and important roles throughout embryogenesis. This review discusses the main features of HGF/SF and its receptor, the product of the c-met protooncogene, and their role in embryogenesis.

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收藏

页码：404 / 410

页数：7

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