IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT

被引：2204

作者：

BOTTARO, DP ^{[1
]}

RUBIN, JS ^{[1
]}

FALETTO, DL ^{[1
]}

CHAN, AML ^{[1
]}

KMIECIK, TE ^{[1
]}

VANDEWOUDE, GF ^{[1
]}

AARONSON, SA ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES & DEV CTR,ABL,BASIC RES PROGRAM,FREDERICK,MD 21702

来源：

SCIENCE | 1991年 / 251卷 / 4995期

关键词：

D O I：

10.1126/science.1846706

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the beta-subunit of the c-met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of I-125-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c-met directly established the c-met product as the cell-surface receptor for HGF.

引用

页码：802 / 804

页数：3

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